Open AccessInfluence of polymorphic loci rs1800629 (TNFa), rs6074022 (CD40), rs187238 (IL-18), rs10492972 (KIF1B), rs4149584 (TNFRSF1A) on clinical features of multiple sclerosis subject to sex belonging in Russian ethnic group
Author(s) -
Ye. V. Khanokh,
Alexey Rozhdestvensky,
Ye. A. Kudryavtseva,
A. V. Kakulya,
R. A. Delov,
M. A. Filipenko
Publication year - 2011
Publication title -
bûlletenʹ sibirskoj mediciny
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.135
H-Index - 3
eISSN - 1819-3684
pISSN - 1682-0363
DOI - 10.20538/1682-0363-2011-2-50-56
Subject(s) - multiple sclerosis , medicine , immunology
To study influence of polymorphic loci rs1800629 (TNFa), rs6074022 (CD40), rs187238 (IL-18), rs10492972 (KIF1B), rs4149584 (TNFRSF1A) on clinical features of multiple sclerosis (MS) subject to sex belonging in Omsk city and Omsk region. Methods: neurological examination, molecular-genetic, statistic analyses. 265 patients with multiple sclerosis and 576 healthy controls was observed. Results: observable polymorphic loci don’t associated with sex. In group of men dysfunction of the pyramidal, visual, pelvic functions on course of MS, in women group — dysfunction of the pyramidal functions, duration of the disease, height, CD40 genotipe.