Open AccessImmunal and biochemical indexes in early diagnostics of chronic brain ischemia
Author(s) -
Екатерина Владимировна Нечунаева,
Г. И. Шумахер,
E Vorobiova,
А. В. Тимошников,
М. А. Хорева
Publication year - 2011
Publication title -
bûlletenʹ sibirskoj mediciny
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.135
H-Index - 3
eISSN - 1819-3684
pISSN - 1682-0363
DOI - 10.20538/1682-0363-2011-2-142-146
Subject(s) - enolase , endothelial dysfunction , brain ischemia , endothelium , medicine , ischemia , autoantibody , endothelin receptor , cardiology , immunology , antibody , immunohistochemistry , receptor
The paper presents results of clinical and laboratory investigation of 106 patients with chronic brain ischemia (CBI) I—II stages, included detection levels of circulating desquamated endothelial cells, endothelin-1, autoantibodies to encephalitogenic protein, neuron-specific enolase and protein S100. Reliable changes of immune status as well as signs of endothelium dysfunction progressed with stage of CBI. Direct correlation between intensity of endothelium dysfunction and activity of neurodegererative process in brain was revealed.