Open AccessAntioxidant activity of thiophane in rats with of experimental tetrachlorolmethane-induced hepatitis
Author(s) -
В. И. Смольякова,
М. Б. Плотников,
Г. А. Чернышёва,
И. С. Иванов,
А. Е. Просенко,
Н. В. Кандалинцева
Publication year - 2010
Publication title -
bûlletenʹ sibirskoj mediciny
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.135
H-Index - 3
eISSN - 1819-3684
pISSN - 1682-0363
DOI - 10.20538/1682-0363-2010-5-98-101
Subject(s) - antioxidant , lipid peroxidation , chemistry , tocopherol , phenol , conjugate , pharmacology , liver tissue , biochemistry , hepatitis , food science , medicine , organic chemistry , vitamin e , mathematical analysis , mathematics
The purpose of this investigation is to study antioxidant activity of sterically hindered phenol — thiophane in rats with toxical hepatitis. Increase of diene and triene conjugates as well as fluorescent products in hepar tissue was revealed. Course intragastric administration of thiophane decreased significantly the content of lipid peroxidation products (diene and triene conjugates, fluorescent products) and held over the α-tocopherol content in hepar tissue.