Open AccessAssociation of cytokines gene polymorphisms (TNF and IL8) with chronic obstructive pulmonary disease development
Author(s) -
Г. Н. Сеитова,
Ekaterina Bukreeva,
И. С. Кремис,
В. П. Пузырёв
Publication year - 2010
Publication title -
bûlletenʹ sibirskoj mediciny
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.135
H-Index - 3
eISSN - 1819-3684
pISSN - 1682-0363
DOI - 10.20538/1682-0363-2010-3-91-97
Subject(s) - tumor necrosis factor alpha , allele , interleukin 8 , pulmonary disease , polymorphism (computer science) , disease , immunology , gene , biology , medicine , genetics , inflammation , pathology
The association of the tumor necrosis TNF-α –308G/A polymorphism and interleukin-8 genetic IL8 –251А/Т polymorphism with the development of the chronic obstructive lung disease (COLD) in two Tomsk populations (Siberian Tatars and Russians) has been studied. The data on interethnic differences in the structure of COLD susceptibility have been obtained. In Siberian Tatars, the TNF –308G allelic variant plays a role in the COLD development. In Russians, no association of the studied genetic markers with COLD was reveled.