Open AccessStudy of the IL-4 and IL-4δ2 interaction with the IL-4R receptors of the I and II types in silico and the effect on the functional activity of mononuclear cells in vitro
Author(s) -
Константин Викторович Горемыкин,
А. Н. Силков,
Б. В. Шилов,
V. Yu. Serebrov,
A.E. Sazonov,
С. В. Сенников
Publication year - 2010
Publication title -
bûlletenʹ sibirskoj mediciny
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.135
H-Index - 3
eISSN - 1819-3684
pISSN - 1682-0363
DOI - 10.20538/1682-0363-2010-3-51-56
Subject(s) - peripheral blood mononuclear cell , in silico , interleukin , receptor , interleukin 1 receptor, type ii , interleukin 4 , interleukin 2 , cytokine , peripheral blood , immunology , chemistry , biology , microbiology and biotechnology , in vitro , interleukin 5 , biochemistry , gene
Alternatively spliced interleukins are very actively studied over the last years. Splice form of IL-4 — IL-4δ2 has antagonistic effects to its full form on proliferative activity of human mononuclear blood cells and their IL-6 production. Antagonistic effects between IL-4 and IL-4δ2 were confirmed and explained in this study due to combination of biochemical and computer methods.