Open AccessFeatures of the immune disbalance during various clinico-pathogenetic variants of acute progressive pulmonary tuberculosis
Author(s) -
О. В. Воронкова,
О. И. Уразова,
V. V. Novitsky,
Ye. G. Churina,
Р. Р. Хасанова,
И. О. Наследникова,
O. V. Filinyuk,
V. A. Serebryakova,
Yu. V. Kolobovnikova,
Ye. L. Nikulina,
Н. П. Пирогова,
I. V. Berezko
Publication year - 2010
Publication title -
bûlletenʹ sibirskoj mediciny
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.135
H-Index - 3
eISSN - 1819-3684
pISSN - 1682-0363
DOI - 10.20538/1682-0363-2010-3-42-50
Subject(s) - tuberculosis , immune system , medicine , immunology , disease , pulmonary tuberculosis , drug , peripheral blood , drug resistance , pathology , biology , microbiology and biotechnology , pharmacology
In article the data, concerning features of cellular composition, proliferative activity and cytokines production of peripheral blood lymphocytes is presented in patients with various clinico-pathogenetic variants of pulmonary tuberculosis: drag-sensitive and drug-resistant infiltrative, disseminated, fibrous-cavernous. It is established that the extensive destructive tuberculosis without dependence from the clinical form of disease is accompanied by the expressed insufficiency of the cellular-mediated mechanisms of immunological resistance both to drag-sensitive, and to drug-resistant M. tuberculosis against quantitative prevalence of B-lymphocytes and intensity of their functional activity.