Open AccessAntitumor in vitro and in vivo effects of lipid composites of cisplatin and ferromagnetic nanoparticles capsulated by carbonic coating
Author(s) -
С. А. Антипов,
Т. А. Федущак,
О. В. Кокорев,
Е. А. Геренг,
G. Ts. Dambayev,
А. Е. Ермаков,
М. А. Уймин,
И. А. Хлусов
Publication year - 2010
Publication title -
bûlletenʹ sibirskoj mediciny
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.135
H-Index - 3
eISSN - 1819-3684
pISSN - 1682-0363
DOI - 10.20538/1682-0363-2010-1-9-16
Subject(s) - in vivo , cisplatin , in vitro , coating , nanoparticle , cytotoxic t cell , materials science , phospholipid , chemistry , cancer research , composite material , nanotechnology , medicine , chemotherapy , biochemistry , biology , microbiology and biotechnology , membrane
An investigation of in vitro and in vivo reaction of adenocarcinoma cells in conditions of direct contact with composites designed in a base of phospholipid concentrate, cisplatin and nanoparticles (diameter less than 10 nm) of iron capsulated by carbonic coating was the aim of paper. Their antitumor effect has been established to be conditioned by direct cytotoxic relatively elective action on malignant cell and, on the other hand, by stimulation of tumor node fibrosis. Proposed biotechnological approach that used low doses of cytostatic drug (1/10 LD50) and nanoferromagnetic particles (2 mg/kg) may be useful to design magnetocontrollable regimes for regional immuno(bio)therapy of cancer and its metastases.