Open AccessFunctional significance of polymorphism of ApoE and SOD2 genes in formation of chronic HCV infection
Author(s) -
N. A. Semyonova,
N. V. Ryazantsevа,
V. V. Novitsky,
A. I. Dmitriyeva,
O. Ye. Chechina,
В. А. Бычков,
I. P. Moiseyenko
Publication year - 2009
Publication title -
bûlletenʹ sibirskoj mediciny
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.135
H-Index - 3
eISSN - 1819-3684
pISSN - 1682-0363
DOI - 10.20538/1682-0363-2009-3-64-68
Subject(s) - sod2 , genotype , gene polymorphism , biology , apolipoprotein e , gene , allele , population , genetics , polymorphism (computer science) , apolipoprotein b , superoxide dismutase , polymerase chain reaction , restriction fragment length polymorphism , virology , immunology , medicine , enzyme , disease , biochemistry , environmental health , cholesterol
The analysis of gene polymorphism plays an important role in assessment of disposition to infectious diseases at the population and individual level. In this paper, the frequencies of allelic versions of apolipoprotein E and 2nd type superoxide dismutase genes and the corresponding genotypes were determined in healthy persons and chronic viral hepatitis type C patients of the Europeoid population of the Tomsk Region. For the analysis of polymorphism of these genes, we used modern genetic methods: polymerase chain reaction and polymorphism of lengths of restriction fragments. For the studied population, it was revealed that the polymorphism of apolipoprotein E and 2nd type superoxide dismutase genes correlates with the development of chronic viral hepatitis type C and with the fibrogenesis process.