Open AccessRole of nitric oxide and cytoskeleton in regulation of contractile activity smooth muscle cells
Author(s) -
С. В. Гусакова,
М. Б. Баскаков,
И. В. Ковалев,
О. С. Мельник,
Л. В. Капилевич,
Mikhail Medvedev,
V. B. Studnitsky,
О. И. Антонов
Publication year - 2009
Publication title -
bûlletenʹ sibirskoj mediciny
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.135
H-Index - 3
eISSN - 1819-3684
pISSN - 1682-0363
DOI - 10.20538/1682-0363-2009-3-17-22
Subject(s) - nocodazole , sodium nitroprusside , nitric oxide , phenylephrine , colchicine , chemistry , microfilament , cytoskeleton , biophysics , depolarization , myocyte , microbiology and biotechnology , medicine , endocrinology , cell , biology , biochemistry , organic chemistry , blood pressure
The influence of modulation of cytoskeleton by colchicine, nocodazole and cytochalasine D on contractile reactions of smooth muscle cells caused by depolarization, phenylephrine end sodium nitroprusside has been investigated by the mechanographical method. It was found that the reduction in smooth muscle cells of rat aorta caused by fenilefrin more sensitive to sodium nitroprusside than the reduction induced hyperpotassium solution. We show that microtubules involved in relaxation, indirect nitric oxide of smooth muscle in hyperpotassium solution, whereas the efficiency of relaxing influence of nitric oxide in rat aorta smooth muscle in the action depends on phenylephrine and microfilaments and microtubules.