Open AccessThe role of cytokines in redox-dependent regulation of apoptosis
Author(s) -
O. Ye. Chechina,
Asel Biktasova,
Ye. V. Sazonova,
О. Б. Жукова,
Т. С. Прохоренко,
I. V. Krat,
N. Yu. Chasovskikh,
V. V. Novitsky,
N. V. Ryazantsevа
Publication year - 2009
Publication title -
bûlletenʹ sibirskoj mediciny
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.135
H-Index - 3
eISSN - 1819-3684
pISSN - 1682-0363
DOI - 10.20538/1682-0363-2009-2-67-71
Subject(s) - apoptosis , reactive oxygen species , tumor necrosis factor alpha , in vitro , recombinant dna , interleukin , chemistry , microbiology and biotechnology , redox , necrosis , immunology , cancer research , cytokine , biology , medicine , biochemistry , gene , organic chemistry
Research of influence of recombinant tumor necrosis factor alpha, interleukin-2 and interleukin-4 in vitro on the apoptosis of lymphocytes is performed. It is revealed that a proapoptotic effect of these cytokines is dose-dependent and is realized with the assistance of reactive oxygen species and mitochondrias.