Open AccessAssociation between <i>VDR</i> polymorphism and multiple sclerosis
Author(s) -
С. А. Бабенко,
В. М. Алифирова,
Yu. Yu. Orlova,
V. P. Pusyryov
Publication year - 2008
Publication title -
bûlletenʹ sibirskoj mediciny
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.135
H-Index - 3
eISSN - 1819-3684
pISSN - 1682-0363
DOI - 10.20538/1682-0363-2008-5-1-40-45
Subject(s) - haplotype , calcitriol receptor , multiple sclerosis , allele , polymorphism (computer science) , genotype , medicine , genetics , biology , immunology , gene , vitamin d and neurology
Genotypes and haplotypes frequencies for VDR polymorphisms in case-control studies of multiple sclerosis (MS) were investigated. Results show an association of VDR T/t variant with diseases ( p < 0,05). This marker was also associated with amount of eosinophils in MS patients ( p < 0,05). Polymorphisms B/b and F/f was associated with ESR level, IgG level and amount of the CD16 + cell ( p < 0,05). We demonstrate that the Bft haplotype significantly higher observed at MS patients and btT — at healthy person Received data allow suggests that the allele t VDR and Bft haplotype of VDR gene could increase susceptibility to MS and have influence on clinical manifestation of diseases.