Open AccessState of antioxidant blood system at physiological pregnancy and pregnancy complicated with bleeding
Author(s) -
Z. I. Mikashinowich,
Ye. V. Olempieva
Publication year - 2008
Publication title -
bûlletenʹ sibirskoj mediciny
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.135
H-Index - 3
eISSN - 1819-3684
pISSN - 1682-0363
DOI - 10.20538/1682-0363-2008-2-101-105
Subject(s) - pregnancy , hydrogen peroxide , antioxidant , microcirculation , medicine , glutathione peroxidase , peroxidase , myeloperoxidase , vasodilation , endothelial dysfunction , obstetrics , chemistry , endocrinology , biochemistry , enzyme , catalase , biology , inflammation , genetics
The task of our investigation was the analysis of enzyme activity of antioxidant defense in women blood at physiological pregnancy and pregnancy complicated with hypertension. It was established that hyper production of hydrogen peroxide and glutathione peroxidase activation at physiological pregnancy improved microcirculation due to vasodilatation effect of hydrogen peroxide. It was established that activation of superoxiddysmutase and myeloperoxidase at pregnancy complicated with hypertension developed endothelial dysfunction owing to citotoxic effects of hydrogen peroxide.