Open AccessActivity of blood kallikrein-kinin and renin-angiotensin systemsin newborns with hypoxic-ishaemic encephalopathy
Author(s) -
G. A. Soukhanova,
Ye. I. Kondratyeva,
T. Ye. Gunbina,
В.В. Горев,
Т. Н. Хлынина
Publication year - 2007
Publication title -
bûlletenʹ sibirskoj mediciny
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.135
H-Index - 3
eISSN - 1819-3684
pISSN - 1682-0363
DOI - 10.20538/1682-0363-2007-2-114-117
Subject(s) - renin–angiotensin system , kallikrein , endocrinology , medicine , hemodynamics , plasma renin activity , hypoxia (environmental) , angiotensin converting enzyme , kinin , angiotensin ii , bradykinin , blood pressure , chemistry , enzyme , receptor , biochemistry , oxygen , organic chemistry
Oxygen insufficiency in newborns is associated with disturbed vascular tone, which are regulated by kallikrein-kinin (KKS) and renin-angiotensin systems (RAS).Important index of hemodynamic disturbances is the activity of kallikrein, of angiotensin-converting enzyme (ACE) and also inhibitors of proteinases: α1-proteinase inhibitor and α2-macroglobulin. In hypoxic-ischemic encephalopathy of mature newborns and children of the I, II premature degrees , blood KKS activity is increased in comparison with RAS. Decreased activity of α1-proteinase inhibitor is seen in 46% of premature infants of II degree which usually leads to chronic pathologic process. The increased activity of ACE is important for preventing hemodynamic disturbances.