Open AccessThe role of opioid peptides in the regulation of secretin-stimulated bile secretion
Author(s) -
Mikhail Medvedev,
I. V. Roudin
Publication year - 2006
Publication title -
bûlletenʹ sibirskoj mediciny
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.135
H-Index - 3
eISSN - 1819-3684
pISSN - 1682-0363
DOI - 10.20538/1682-0363-2006-3-37-41
Subject(s) - secretin , medicine , endocrinology , agonist , opioid , exenatide , chemistry , secretion , opioid peptide , opioidergic , receptor , (+) naloxone , diabetes mellitus , type 2 diabetes
Influence of intraperitoneal dalargin (dand m-opioid agonist), DADLE (d-opioid agonist), DAGO (m-opioid agonist) and U50488 (k-opioid agonist) on bile secretion which is stimulated by secretin was studied in sharp experiments on white rats. All opioids studied is demonstrated to suppress secretory response of liver upon secretin in different extent. We suppose that opioidergic regulation system has different effect on bile secretion in dependence of baseline level of physiologic secretion.