Open AccessThe role of μ-opioid receptors in the regulation of hepatic secretory function
Author(s) -
Mikhail Medvedev,
И. В. Рудин,
A. F. Garayeva
Publication year - 2006
Publication title -
bûlletenʹ sibirskoj mediciny
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.135
H-Index - 3
eISSN - 1819-3684
pISSN - 1682-0363
DOI - 10.20538/1682-0363-2006-2-90-95
Subject(s) - endocrinology , medicine , opioid , secretion , agonist , receptor , chemistry , biology
Influence of intraperitoneal and intracerebroventricular DAGO (μ-opioid agonist) on the bile secretion and composition was studied in white rats having intact and denervated liver. DAGO was demostrated to alter bile composition significantly both intraperitoneally and intracerebroventricularly and these effects were opposite. Intact liver innervation is a necessary condition for intracerebroventricular DAGO to have its effect on bile secretion.