Open AccessThe role of stem cells in the recovery of hemopoiesis in cytostatic and radial myelosuppressions
Author(s) -
Ye. D. Goldberg,
А. М. Дыгай,
В. В. Жданов
Publication year - 2006
Publication title -
bûlletenʹ sibirskoj mediciny
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.135
H-Index - 3
eISSN - 1819-3684
pISSN - 1682-0363
DOI - 10.20538/1682-0363-2006-2-35-42
Subject(s) - haematopoiesis , stromal cell , stem cell , radioresistance , bone marrow , biology , microbiology and biotechnology , immunology , cancer research , cell culture , genetics
The development of hemopoietic tissue hypoplasia and recovery of hemopoietic dynamics in addition to the direct suppressive effect of toxic agents on hemopoietic cells are mainly due to the character of hemopoietic disregulation were shown on different models of myelosuppressions (irradiation, injecting cytostatic drugs having different action mechanisms). At the same time, compensatory changes of blood system and underlying mechanisms are mainly non-specific and of the same type. Creation of reparative processes in the hemopoietic tissue is significantly by bone marrow stromal cells thanks to chemioand radioresistance of their precursors (mesenchimal stem cells).