Open AccessMechanisms of bronchial asthma control disturbance in using 2-agonists
Author(s) -
N. V. Vas'kovsky,
Ye. S. Koulikov
Publication year - 2006
Publication title -
bûlletenʹ sibirskoj mediciny
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.135
H-Index - 3
eISSN - 1819-3684
pISSN - 1682-0363
DOI - 10.20538/1682-0363-2006-1-67-72
Subject(s) - bronchospasm , desensitization (medicine) , asthma , b2 receptor , medicine , methacholine , immunology , respiratory disease , receptor , lung , bradykinin
Despite exclusively high clinical efficacy of 2-agonists in bronchospasm, their regular using is associated with increased level of bronchial asthma control and the development of severe and life-threatening states which in turn is associated with increasing bronchial hyper-reactivity, development of partial tolerance, increased allergic load and masking of the disease aggravation. Deve- lopment of tolerance to 2-agonists and increasing sensibility of bronchi to bronchoconstrictive stimuli are based on specific mecha-nisms including desensitization of 2-adrenoreceptor, increasing expression of C phospholipase and mechanisms associated with gene AP variants which are not studied enough.