Open AccessProduction of cytokines by cell-effectors of natural cytotoxicity system in mice under development of Lewis lung carcinoma
Author(s) -
Ye. Yu. Sherstoboyev,
Olexandr Kaplya,
Ye. P. Zuyeva,
Т. Г. Разина,
Oleg Epstein
Publication year - 2004
Publication title -
bûlletenʹ sibirskoj mediciny
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.135
H-Index - 3
eISSN - 1819-3684
pISSN - 1682-0363
DOI - 10.20538/1682-0363-2004-2-24-29
Subject(s) - lewis lung carcinoma , cytotoxicity , tumor necrosis factor alpha , cytokine , effector , immunology , cytotoxic t cell , cancer research , biology , medicine , cancer , biochemistry , in vitro , metastasis
Cytokine production by cell-effectors of natural cytotoxicity system under Lewis lung carcinoma development in F1(CBAxC57B1/6) line mice has been studied. It has been revealed the increase of interleukin-1β (IL-1β) production and tumor necrosis factor-α (TNF-α) by peritoneal macrophages. At this the balance of cytokines produced by T-helpers (Th) has been displaced to Th2 side, IL-4 production has increased and interferon-γ (IFN-γ) and IL-2 production has decreased. The rise of IL-10 production by lymphocytes has been observed in the later terms of tumor development.