Open AccessEffect of polyphenol-containing hepatoprotectors on functional liver morphology during experimental Reye’s syndrome
Author(s) -
L. A. Shamardina
Publication year - 2003
Publication title -
bûlletenʹ sibirskoj mediciny
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.135
H-Index - 3
eISSN - 1819-3684
pISSN - 1682-0363
DOI - 10.20538/1682-0363-2003-4-41-46
Subject(s) - steatosis , lobules of liver , hepatocyte , parenchyma , necrosis , fatty liver , intracellular , enzyme , reye syndrome , biology , chemistry , pathology , endocrinology , biochemistry , medicine , in vitro , disease
During experimental Reye’s syndrome caused in rats by 4-pentenoic acid, histoarchitectonics disturbances, circulatory disturbances, microvesicular steatosis, necrosis in central lobule part have been developed, number of 2-nucleus cells has been decreased, activity of mitochondrial, lysosomal and cytoplasmic hepatocyte enzymes has been disturbed. Hepatoprotectors of polyphenol nature — lochein , maksar and legalon — used for experimental Reye’s syndrome therapy, have regenerated a normal liver histologic structure, decreased the microvesicular steatosis and the quantity of necrotizing parenchyma cells, stimulated the regeneration and increased the activity of intracellular hepatocyte enzymes. Lochein and maksar possess the most therapeutic activity.