Open AccessExogenic and endogenic factors in chronic obstructive pulmonary disease forming
Author(s) -
Ekaterina Bukreeva,
С. А. Богушевич,
Е. А. Дементьева,
Г. Э. Черногорюк,
С. В. Нестерович,
Г. Н. Сеитова,
С. В. Буйкин
Publication year - 2003
Publication title -
bûlletenʹ sibirskoj mediciny
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.135
H-Index - 3
eISSN - 1819-3684
pISSN - 1682-0363
DOI - 10.20538/1682-0363-2003-1-75-77
Subject(s) - copd , pulmonary disease , genotyping , allele , medicine , disease , elastin , gene , pathology , genetics , genotype , biology
To determine the role of exogenic and endogenic factors in chronic obstructive pulmonary disease (COPD) forming 100 patients (50 patients are control group) were examined by means of clinical and genealogical researches, including family tree composition with analisis of 3—4 generations, genotyping on the most wide-spread α1-proteinase inhibitor (α1-PI) gene alleles (M, S, Z), definition of the α1-PI level in the serum. The role of exogenic factors (smoking, pollutants) have been confirmed in COPD forming, while primery α1-PI deficiency have been revealed only in 6% COPD patients. Therefore, further investigations of other genetic alleles in COPD patients are necessary.