Open AccessAirway hyperresponsiveness in bronchial asthma: pathogenesis basics
Author(s) -
И. А. Деев,
И В Петрова,
Е. Г. Кармалита,
Ф. И. Петровский,
Л. М. Огородова
Publication year - 2002
Publication title -
bûlletenʹ sibirskoj mediciny
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.135
H-Index - 3
eISSN - 1819-3684
pISSN - 1682-0363
DOI - 10.20538/1682-0363-2002-4-65-74
Subject(s) - bronchial hyperresponsiveness , asthma , medicine , pathogenesis , immunology , airway hyperresponsiveness , bronchial obstruction , inflammation , airway , bronchus , bronchial hyperreactivity , respiratory disease , lung , anesthesia
Bronchial asthma has three main components: persistent bronchial inflammation, reversible bronchial obstruction and bronchial hyperresponsiveness to nonspecific triggers. Airway hyperresponsiveness is a complex phenomenon that develops upon the influence of chronic inflammation, high total IgE, changes in bronchial smooth muscle cells functioning, structural changes in bronchial wall and disturbances in neural regulation of bronchial tone.