Open AccessGenetic variability antioxidant activity of blood plasma in urban population (Seversk) of Tomsk region
Author(s) -
А. В. Марусин,
V. P. Puzyryov,
V. B. Salyukov,
E. Yu. Bragina
Publication year - 2002
Publication title -
bûlletenʹ sibirskoj mediciny
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.135
H-Index - 3
eISSN - 1819-3684
pISSN - 1682-0363
DOI - 10.20538/1682-0363-2002-3-24-30
Subject(s) - biology , allele , genetic variation , antioxidant , genetic variability , glutathione peroxidase , genetics , population , polymorphism (computer science) , gene , biochemistry , genotype , superoxide dismutase , demography , sociology
Antioxidant activity (AOA) was measured in 185 inhabitants of the town of Seversk (members of 43 families and unrelated individuals). AOA was defined on the ability of a blood plasma to reduce an output of products, reacting with thiobarbituric acid in the model system «lecithine-Fe 2 + -ions». Polymorphism of gastrointestinal glutathione peroxidase (GPX2) gene (two-allelic dinucleotide (TC)n repeat polymorphism) was investigated in 208 individuals. The presence of seasonal changes was revealed and no influences of sex and age on AOA in the considered group were shown. Approximately 50% variance in total AOA was due to the additive effects of genes. No statistical significant association between genetic variability of GPX2 and AOA variation was revealed. Estimation of GPX2 genetic variability contribution to AOA level was 2.53%.