Open AccessCell immunity at pregnant women with autoimmune thyroiditis and gestosis
Author(s) -
A. Sh. Makhmuthodzhayev,
Л. М. Огородова,
И. Д. Евтушенко,
A. V. Holopov,
Е. Л. Тимошина,
E. V. Makhmuthodzhayeva
Publication year - 2002
Publication title -
bûlletenʹ sibirskoj mediciny
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.135
H-Index - 3
eISSN - 1819-3684
pISSN - 1682-0363
DOI - 10.20538/1682-0363-2002-1-57-62
Subject(s) - preeclampsia , medicine , cd8 , gestation , immunology , pregnancy , autoimmune thyroiditis , thyroiditis , lymphocyte , immunity , cd16 , major histocompatibility complex , cd3 , endocrinology , immune system , thyroid , biology , genetics
In a prospective study the group of 60 women with AIT and thyroidological uneventful control women, matched for age and parity ( n = 30) were tested at 12 and 32 weeks gestation for percentages of peripheral blood lymphocyte subsets (CD3, CD4, CD8, CD16, HLA-DR major histocompatibility complex (MHC)-class II), IL-2, IFN-gamma, TPO-Abs, TSH and thyroxin. Twenty five pregnant women with AIT (41,7%) developed preeclampsia (against 16,7% in control). Pregnancyrelated CMI alterations consisted of low percentages of CD16 + NK cells and all subpopulations of T-cells at 12 weeks gestation. The development of preeclampsia in women with AIT was accompanied with increasing percentage of HLADR + T- lymphocytes. The high levels of TPO-Abs and activated T-lymphocytes in pregnant women with autoimmune thyroiditis has been suggested as a predictor for later preeclampsia development.