Open AccessThe effectiveness of cytocardioprotection of patients with the moderately expressed post infarct dysfunction of left heart ventricle: the results of the randomization research of trimetazidine and athenolole
Author(s) -
V. V. Kalyuzhin,
М. А. Соловцов,
Dmitrii Kamaev
Publication year - 2002
Publication title -
bûlletenʹ sibirskoj mediciny
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.135
H-Index - 3
eISSN - 1819-3684
pISSN - 1682-0363
DOI - 10.20538/1682-0363-2002-1-40-44
Subject(s) - trimetazidine , atenolol , ventricle , cardiology , medicine , preload , randomization , blood pressure , contractility , myocardial infarction , heart rate , clinical trial , hemodynamics
With the purpose of research of clinical efficiency of trimetazidine and atenolol and their influence on morfofunctional parameteres of left ventricle 36 men who have transferred a myocardial infarction are inspected. Patients were randomly divided into 2 groups. Clinical status and function state of left ventricle (by echocardiography) was assessed before and after 4-week therapy with trimetazidine or atenolol. Atenolol and trimetazidine have shown in our study identical clinical efficiency. However while atenolol is statistically significant reduced systolic arterial pressure and heart rate, thickness of posterior wall of left ventricle and corrects diastolic function, trimetazidine had no such activity. Treatment with trimetazidine promoted improvement of local contractility of left ventricle.