Open AccessIdentification of antibiotic resistance patterns in Helicobacter pylori strains isolated from gastric biopsies using real-time PCR and genotypic analysis
Author(s) -
Juanita Ann Spiteri,
Graziella Zahra,
John Schembri,
Anthea Pisani,
Elaine Borg,
Neville Spiteri,
Eliezer Zahra Bianco,
Paul Caruana,
Julia Gauci,
Mark Muscat,
Christopher Barbara,
Pierre Ellul
Publication year - 2021
Publication title -
annals of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.886
H-Index - 33
eISSN - 1792-7463
pISSN - 1108-7471
DOI - 10.20524/aog.2021.0624
Subject(s) - clarithromycin , medicine , helicobacter pylori , gastroenterology , rapid urease test , amoxicillin , metronidazole , antibiotics , antibiotic resistance , gastritis , concordance , proton pump inhibitor , microbiology and biotechnology , biology
Helicobacter pylori (H. pylori) is associated with dyspepsia, mucus-associated lymphoid tissue lymphoma, gastritis, and peptic ulcer disease. Treatment in Malta consists of triple therapy, which consists of a proton pump inhibitor and 2 of the antibiotics amoxicillin, clarithromycin, metronidazole and fluoroquinolones. We aimed to determine the resistance rates for clarithromycin and fluoroquinolones in patients with H. pylori , and its incidence, in patients undergoing an esophagogastroduodenoscopy (EGD) using real-time polymerase chain reaction (RT-PCR).