Open AccessDiagnostic utility of low hemoglobin density to detect iron deficiency in patients with inflammatory bowel disease
Author(s) -
Karima Farrag,
Krenare Ademaj,
E Leventi,
A Aksan,
Jürgen M. Stein
Publication year - 2021
Publication title -
annals of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.886
H-Index - 33
eISSN - 1792-7463
pISSN - 1108-7471
DOI - 10.20524/aog.2021.0622
Subject(s) - medicine , anemia , gastroenterology , ferritin , iron deficiency , transferrin saturation , iron deficiency anemia , hemoglobin , biomarker , inflammatory bowel disease , anemia of chronic disease , receiver operating characteristic , gold standard (test) , disease , biochemistry , chemistry
In the absence of a feasible noninvasive gold standard, iron deficiency (ID) anemia (IDA) is best measured using multiple indicators. However, the choice of an appropriate single iron biomarker for ID screening continues to be debated. Low hemoglobin density (LHD%) from Coulter counters has been suggested as a useful tool to detect ID. This study investigated the reliability of LHD% for the assessment of iron status in patients with inflammatory bowel disease (IBD) and IDA, anemia of chronic disease (ACD) or mixed anemia (MIX).