Open AccessDeletion of the Lmna gene in fibroblasts causes senescence-associated dilated cardiomyopathy by activating the double-stranded DNA damage response and induction of senescence-associated secretory phenotype
Author(s) -
Leila Rouhi,
Gaëlle Auguste,
Qiong Zhou,
Raffaella Lombardi,
Melis Olcum,
Kimia Pourebrahim,
Sirisha Cheedipudi,
Saman Asghar,
Kui Hong,
Matthew J. Robertson,
Cristian Coarfa,
Priyatansh Gurha,
Ali J Marian
Publication year - 2022
Publication title -
the journal of cardiovascular aging
Language(s) - English
Resource type - Journals
ISSN - 2768-5993
DOI - 10.20517/jca.2022.14
Subject(s) - lmna , biology , senescence , dilated cardiomyopathy , cancer research , pdgfra , lamin , myocyte , cardiomyopathy , cardiac fibrosis , microbiology and biotechnology , medicine , endocrinology , heart failure , gene , genetics , gist , stromal cell