Open AccessPharmacological suppression of the WNT signaling pathway attenuates age-dependent expression of the phenotype in a mouse model of arrhythmogenic cardiomyopathy
Author(s) -
Sirisha Cheedipudi,
Siyang Fan,
Leila Rouhi,
Ali J Marian
Publication year - 2021
Publication title -
the journal of cardiovascular aging
Language(s) - English
Resource type - Journals
eISSN - 2768-5993
DOI - 10.20517/jca.2021.04
Subject(s) - wnt signaling pathway , medicine , myh6 , cardiomyopathy , myocardial infarction , myocardial fibrosis , phenotype , endocrinology , apoptosis , fibrosis , cardiology , signal transduction , heart failure , biology , microbiology and biotechnology , gene , genetics , myh7 , gene isoform
Arrhythmogenic cardiomyopathy (ACM) is a genetic disease of the myocardium, characterized by cardiac arrhythmias, dysfunction, and sudden cardiac death. The pathological hallmark of ACM is fibro-adipocytes replacing cardiac myocytes. The canonical WNT pathway is implicated in the pathogenesis of ACM.