Open AccessHistological analysis of thrombi retrieved after acute ischemic stroke from large vessel occlusion: from research to clinical practice
Author(s) -
Ettore Nicolini,
Manuela De Michele,
Anne Falcou,
Luca Petraglia,
Irene Berto,
Danilo Toni
Publication year - 2022
Publication title -
vessel plus
Language(s) - English
Resource type - Journals
ISSN - 2574-1209
DOI - 10.20517/2574-1209.2021.78
Subject(s) - thrombus , medicine , etiology , stroke (engine) , radiological weapon , acute stroke , clinical practice , ischemic stroke , occlusion , cardiology , radiology , intensive care medicine , ischemia , physical therapy , tissue plasminogen activator , mechanical engineering , engineering
Emergent reperfusion therapies have improved acute ischemic stroke prognosis, but many patients are still bound to bad clinical outcome, probably because of our incomplete knowledge of its pathophysiology. Thanks to mechanical thrombectomy, occluding material is available for histological analysis. Several studies investigated the possible relationship between thrombus composition and clinical, procedural, and radiological variables of acute ischemic stroke. The potential value of thrombus analysis as a tool for clinical practice and research is still not defined, as data from the literature are heterogeneous and sometimes conflicting. We propose a review of the existing literature regarding histological analysis of thrombi in acute ischemic stroke. We classified articles on clot composition according to the clinical variable explored in each study. We first distinguished articles about etiology, procedural, and radiological variables, and then we performed a subclassification for each group. This review could help both in the interpretation of thrombus analysis in clinical practice and in its usage for future research.