Open AccessHepatocellular carcinoma on the background of nonalcoholic fatty liver disease: epidemiological update
Author(s) -
Elvire Desjonqueres,
Elia Gigante
Publication year - 2022
Publication title -
hepatoma research
Language(s) - English
Resource type - Journals
eISSN - 2454-2520
pISSN - 2394-5079
DOI - 10.20517/2394-5079.2021.136
Subject(s) - hepatocellular carcinoma , medicine , nonalcoholic fatty liver disease , fatty liver , epidemiology , disease , liver disease , chronic liver disease , metabolic syndrome , diabetes mellitus , viral hepatitis , alcoholic liver disease , obesity , gastroenterology , cirrhosis , endocrinology
The epidemiological features of hepatocellular carcinoma have changed significantly in the last decades. While for a long-time viral hepatitis and alcohol consumption have been the leading risk factors, the current spread of obesity and type 2 diabetes has contributed to the emergence of non-alcoholic fatty liver disease (NAFLD) worldwide, which has become the leading chronic liver disease as well as one of the main etiologies of hepatocellular carcinoma (HCC), especially in western countries. In this review, we resume the latest data about the epidemiology of metabolic liver disease and HCC arising from NAFLD and discuss the main clinical and molecular features leading to the progression of liver disease and the development of HCC in NAFLD. The emerging concept of metabolic associated fatty liver disease and its association with the development of HCC are also introduced.