Open AccessAnti-aging and anti-carcinogenic effects of 1α, 25-dihyroxyvitamin D3 on skin
Author(s) -
Neena Philips,
Mikel Portillo-Esnaola,
Samuel Philips,
María Gallego-Rentero,
Teresa Keller,
Jan Franco
Publication year - 2022
Publication title -
pastic and aesthetic research
Language(s) - English
Resource type - Journals
eISSN - 2349-6150
pISSN - 2347-9264
DOI - 10.20517/2347-9264.2021.83
Subject(s) - angiogenesis , photoaging , matrix metalloproteinase , extracellular matrix , oxidative stress , medicine , carcinogenesis , elastin , vascular endothelial growth factor , inflammation , cancer research , microbiology and biotechnology , endocrinology , pathology , cancer , biology , dermatology , vegf receptors
Photoaging and carcinogenesis are facilitated by oxidative stress, inflammation, angiogenesis, and extracellular matrix (ECM) remodeling. Oxidative effects include DNA damage, membrane oxidation, lipid peroxidation, and alterations in the expression of p53 and antioxidant enzymes. The inflammatory and angiogenesis mediators include interleukin-1, tumor necrosis factor-α, interleukin-8, transforming growth factor-β, and vascular endothelial growth factor. ECM remodeling includes alterations in the expression and organization of collagen, elastin, matrix metalloproteinases, and elastase. 1α, 25-dihydroxy-vitamin D3 has antioxidant, anti-inflammatory, and ECM regulatory properties, and can counteract the processes that facilitate photoaging and carcinogenesis. This review provides an overview of the beneficial effects of vitamin D supplementation at a molecular level, followed by a brief discussion regarding its use as a supplement.