Open AccessConnective Tissue Growth Factor in Normal and Pathological Processes
Author(s) -
С. В. Тополянская
Publication year - 2020
Publication title -
arhivʺ vnutrennej mediciny
Language(s) - English
Resource type - Journals
eISSN - 2411-6564
pISSN - 2226-6704
DOI - 10.20514/2226-6704-2020-10-4-254-261
Subject(s) - connective tissue , growth factor , extracellular matrix , ctgf , microbiology and biotechnology , wound healing , angiogenesis , biology , fibrosis , pathology , cancer research , immunology , medicine , biochemistry , genetics , receptor
Modern concepts about the role of connective tissue growth factor in various physiological and pathological processes are described in the review. Connective tissue growth factor regulates a variety of cellular functions, including proliferation, migration, adhesion, differentiation and synthesis of extracellular matrix proteins in cells of different types. This factor is also involved in more complex biological processes of angiogenesis, chondrogenesis, wound healing, fibrosis and oncogenesis. Increased expression of connective tissue growth factor is observed in different cardiovascular and oncological diseases. Potential role of this growth factor in regulation of cellular senescence and aging processes is also discussed.