Open AccessLIPID METABOLISM DISORDERS IN PATIENTS WITH CHRONIC HEPATITIS C
Author(s) -
Л И Ткаченко,
В В Малеев,
Д. М. Сариева
Publication year - 2015
Publication title -
arhivʺ vnutrennej mediciny
Language(s) - English
Resource type - Journals
eISSN - 2411-6564
pISSN - 2226-6704
DOI - 10.20514/2226-6704-2015-0-6-50-56
Subject(s) - insulin resistance , steatosis , dyslipidemia , medicine , lipid metabolism , viral load , endocrinology , body mass index , lipid profile , fatty liver , carbohydrate metabolism , hepatitis c virus , hepatitis c , insulin , gastroenterology , diabetes mellitus , cholesterol , obesity , immunology , virus , disease
Purpose of the study. To study lipid metabolism in chronic hepatitis C and to assess its impact on the formation of insulin resistance, steatosis and progression of liver fibrosis. Materials and methods. The study included 205 patients with chronic hepatitis C (CHC). Conducts research, depending on the genotype C, viral load and body mass index (BMI) of the patients. Results. CHC patients revealed a combined hyperlipoproteinemia on the background of op-pression synthesis of apolipoproteins A1 and B. Formation of hepatic steatosis was associated with HCV genotype 3 virus-induced viral load at ≥ 6 log10 IU/ml and metabolic in VL 5 log10 ME/ml signifi cantly increased the risk of lipid and carbohydrate metabolism.