Open AccessAnalysis of Some Hematological and Biochemical Markers in Women Cancer Patients Receiving Doxorubicine Chemotherapy
Author(s) -
Islam Boulaares,
Guemari Imane Yousra,
Samir Derouiche
Publication year - 2020
Publication title -
pharmaceutical and biosciences journal
Language(s) - English
Resource type - Journals
ISSN - 2582-0540
DOI - 10.20510/ukjpb/8/i1/1581327899
Subject(s) - creatinine , medicine , lipid profile , chemotherapy , eosinophil , cancer , lymphocyte , gastroenterology , lipid peroxide , renal function , immunology , oxidative stress , lipid peroxidation , cholesterol , asthma
The goal of this study is to evaluate the effect of Doxorubicine chemotherapy on some biochemical and hematological markers in female cancer's patients. 22 cases of women cancer and control were chosen, Blood samples were collected from them and lipid profile, creatinine, urea levels and enzyme activities were measured. Also, erythrocyte and leucocyte line levels in blood was measured. Results of biochemical parameters revealed that a significant increase in serum lipid profile, creatinine level, LDH, GOT, GPT and GGT activities and no significant change in serum urea level in women with cancer compared to controls. On the other hand, Results of the haematological analysis show that RBC, HGB, HCT and lymphocyte (p <0.01) level are significant decreased in patients compared to control group and no significant change in WBC, Neutrophil , Monocyte , Eosinophil and basophile in patients compared to control group. In conclusion, the present study suggests that doxorubicin affect some biochemical and hematological marker of cardiac function indicating the cardiotoxic as a side effect of this treatment in cancer patients.