Open AccessEvaluation of Chemoprotective and Anticarcinogenic Activity of Cuscuta reflexa
Author(s) -
Shweta Mishra,
Jignyasha Amit Rawal,
Ram Kumar Sahu
Publication year - 2019
Publication title -
pharmaceutical and biosciences journal
Language(s) - English
Resource type - Journals
ISSN - 2582-0540
DOI - 10.20510/ukjpb/7/i5/1580547431
Subject(s) - chemoprotective , antioxidant , traditional medicine , acute toxicity , micronucleus , micronucleus test , chemistry , toxicity , pharmacology , biology , toxicology , biochemistry , medicine , organic chemistry
The plant products are best option for the treatment of cancer due to its lower side effects. In the present study, it was planned to evaluate the chemopreventive and anticarcinogenic activity of Cuscuta reflexa extract in experimental rats. The hydroalcoholic extract was prepared, and acute toxicity, anticarcinogenicity activity and Chemopreventive effect were evaluated. The hydroalcoholic extract was free from toxicity upto dose of 5000 mg/kg body weight. The present investigation showed significant effect of the hydroalcoholic extract (250 and 500 mg/kg) in preventing melanoma tumor by B16F10 cell line in experimental animals. The result of micronucleus assay indicate that hydroalcoholic extract (250 and 500 mg/kg) have preventive potential against cyclophosphamide induced micronucleus formation in experimental animals. The findings suggested that the anticarcinogenicity and chemopreventive activity of Cuscuta reflexa may be due to antioxidant activity.