Open AccessEmerging Trends in Ocular Drug Delivery Special Reference to In Situ Ophthalmic Gel
Author(s) -
Ram Garg,
Vikas Kumar,
Vandana Sharma
Publication year - 2019
Publication title -
pharmaceutical and biosciences journal
Language(s) - English
Resource type - Journals
ISSN - 2582-0540
DOI - 10.20510/ukjpb/7/i3/185553
Subject(s) - drug delivery , bioavailability , contact lens , niosome , dosage form , cornea , in situ , nanotechnology , materials science , biomedical engineering , chemistry , chromatography , ophthalmology , pharmacology , medicine , organic chemistry , biochemistry , vesicle , membrane
Eye is the most complex and valuable organ of the body, because of its prompt pre-corneal elimination of dosage form. In order to overcome this, researchers developed a new system; in-situ gel forming system. This formulation undergoes phase transition in the eye to form gel, thus prolonging the precorneal contact time which will result in improved visual bioavailability. There are different novel ocular drug delivery systems such as In-situ gel, dendrimers, niosomes, nanoparticulate system, collagen shield, ocular iontophoresis suspension and ocusert etc. This framework comprises of polymer or mixture of polymers which display sol-gel transition due to physicochemical parameters (temperature, ion exchange & pH) of the body. This novel drug delivery system promotes the importantly ease and convenience of administration, deliverance of accurate dose as well as to prolong residence time of drug in contact with mucosa. This review incorporates different temperature, pH, and ion induced in situ-forming polymeric systems used to achieve prolonged contact time of drugs with the cornea and increment their bioavailability.