Open AccessTNF: A signaling pathway related to the activation of NF-κB
Author(s) -
Noha Lotfy Ibrahim
Publication year - 2014
Publication title -
pharmaceutical and biosciences journal
Language(s) - English
Resource type - Journals
ISSN - 2582-0540
DOI - 10.20510/ukjpb/2/i3/91166
Subject(s) - lymphotoxin , tumor necrosis factor alpha , lymphotoxin beta receptor , nf κb , cytokine , inflammation , cancer research , immunology , signal transduction , regulator , lymphotoxin alpha , receptor , apoptosis , microbiology and biotechnology , tumor necrosis factors , nfkb1 , biology , medicine , transcription factor , gene , genetics
Tumor necrosis factor (TNF or TNF-α) was formerly suggested as a circulating factor which can cause necrosis of tumors, before it has been known as a key regulator of some pleiotropic functions such as apoptosis, cell survival, inflammation, and immunity acting via two receptors (TNFR-1, TNFR-2). TNF-β or lymphotoxin (LT) has similar biologic effects as TNF-α; however it is produced in much smaller quantities and is a locally acting cytokine. This article discusses the biological function of TNF focusing on its role in cancer and autoimmune diseases via classical activation pathway of nuclear factor kappa-B (NF-κB).