Open AccessPenurunan progesterone-induced blocking factor (PIBF) sebagai penanda preeklampsia
Author(s) -
Achmad Salman,
Budi Wicaksono,
Erry Gumilar Dachlan,
Widjiati Widjiati
Publication year - 2018
Publication title -
majalah obstetri and ginekologi/majalah obstetri dan ginekologi
Language(s) - English
Resource type - Journals
eISSN - 2598-1013
pISSN - 0854-0381
DOI - 10.20473/mog.v24i12016.13-18
Subject(s) - preeclampsia , medicine , placenta , andrology , pregnancy , pathogenesis , gynecology , endocrinology , biology , fetus , genetics
Background: Pathogenesis of preeclampsia still a controversial research objects. Progesterone induced blocking factor has protective effects in pregnancy.Objectives: To compare PIBF serum level and placental weight and investigate correlation between both in preeclampsia.Methods: This experimental study used 16 Mus musculus with normal pregnancy and 16 Mus musculus that were injected with anti Qa-2 to create a preeclampsia model. Terminations of were performed in day 16th, followed by ELISA examination for PIBF serum level and placental weight measurement.Result: PIBF serum level significantly reduced on preeclampsia model compared with control (33,21±29,36 ng/ml vs 105,76±59,69 ng/ml; p 0,05). There was no significant correlation between PIBF serum level and placental weight.Conclusion: Decreased of PIBF serum level could be used as a marker of preeclampsia. Decreased of PIBF serum level may be correlate with placental pathology in preeclampsia.