Open AccessThe Use of Aloe vera Gel on Scar Collagen
Author(s) -
Amania Nur Alam,
Muhammad Jailani,
Siti Hajar
Publication year - 2021
Publication title -
jurnal rekonstruksi dan estetik
Language(s) - English
Resource type - Journals
eISSN - 2774-6062
pISSN - 2301-7937
DOI - 10.20473/jre.v4i2.28224
Subject(s) - aloe vera , antiseptic , traditional medicine , wound healing , disinfectant , negative control , positive control , saponin , chemistry , medicine , surgery , pathology , alternative medicine
Aloe vera have active chemicals substances including saponins, tannins, flavonides, and polyphenols. Saponin takes a role as a disinfectant, so it is normally effective for healing any open wounds, while tannins have ability to be an antiseptic. This study aims to see how the effect of the Aloe vera gel on wound collagen, and too inspect which is the most effective concentration of the Aloe vera gel in the formation of wound collagen in wistar strains (Rattus novergicus) rats. This study uses a post-test only method with control group design. The subjects of this study were 28 male Wistar rats (Rattus novergicus). The subjects were divided into 4 groups consisting of 1 negative control group and 3 treated groups, the control group was not given any treatment, while the treated group was given the Aloe vera gel with each concentrations of 12.5%, 25%, and 50% respectively. The experiment was started by making a wound on the back of the rat which then be followed by applying the gel to the wound for 14 days. The results showed the group with the 50% Aloe vera gel treatment had the best collagen formation, followed by a concentration of 25%, 12.5%, and the control group. Therefore, the used of Aloe vera has given good change in scar collagen, and the best scar collagen can be viewed in the group with 50% concentrate of Aloe vera.