Open AccessMesenchymal Stem Cells and Clinical Application in Chronic Lung Diseases
Author(s) -
Isti Mardiana Soetartio,
Triya Damayanti
Publication year - 2021
Publication title -
jurnal respirasi
Language(s) - English
Resource type - Journals
eISSN - 2621-8372
pISSN - 2407-0831
DOI - 10.20473/jr.v7-i.3.2021.145-151
Subject(s) - mesenchymal stem cell , stem cell , stem cell transplantation for articular cartilage repair , clinical uses of mesenchymal stem cells , microbiology and biotechnology , adult stem cell , biology , immunology , multipotent stem cell , adipose tissue , endothelial stem cell , progenitor cell , in vitro , endocrinology , biochemistry
Mesenchymal stem cells are a multipotent mature non hematopoietic stem cells, with characteristics such as ability to self-renew and differentiate in mesodermal, ectodermal, and endodermal pathway. Mesenchymal stem cells also secrete cytokine and immunoreceptor which regulate micro environment in host tissues and angiogenic mediators which are able to improve damaged tissues. Mesenchymal stem cells are obtained from the human body by isolation, culture, proliferation, characterization, and/or differentiation originating from fat cells (adipose), periosteum tissue, and other tissues from the body. Mesenchymal stem cells can be obtained by autologous and allogenic way. Stem cell processing includes isolation, proliferation, differentiation, and temporary storage for clinical application adhering to good drug manufacturing practice. Approach to cell therapy and bioengineering in lung disease is rapidly developing in the last 10 years. In the current era of cell therapy and transplantation, a lot of research has been done to understand and develop mesenchymal stem cells as a therapeutic alternative, particularly in respiratory area.