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Imunopatogenesis Penyakit Paru Obstruktif Kronik
Author(s) -
Resti Yudhawati,
Yuyus Dwi Prasetiyo
Publication year - 2019
Publication title -
jurnal respirasi
Language(s) - English
Resource type - Journals
eISSN - 2621-8372
pISSN - 2407-0831
DOI - 10.20473/jr.v4-i.1.2018.19-25
Subject(s) - immunology , copd , proinflammatory cytokine , innate immune system , inflammation , medicine , acquired immune system , cd8 , immune system , psychiatry
Chronic Obstructive Pulmonary Disease (COPD) is an inflammatory airway disease and complicated lung tissue. The airways of patients with COPD contain many inflammatory cells including neutrophils, macrophages, CD8 T lymphocytes, CD4 T lymphocytes and dendritic cells, each of which has its own role and interacts with COPD immunopathogenesis. The inflammatory response in people with COPD involves innate immunity (neutrophils, macrophages, eosinophils, mast cells, natural killer cells, and dendritic cells) and adaptive immunity (T and B lymphocytes), but there is also activation of structual cells such as alveolar epithelial cells endothelial cells and fibroblasts. Inflammation of the respiratory tract in COPD will persist even after quitting smoking, this can be caused by damage to the extracellular matrix will release proinflammatory cytokines which are neutrophil and monocyte chemotaxis, impaired alveolar macrophages which result in impaired cleaning of apoptotic cells and pathogenic microbes and oxidative stress will cause DNA double chain damage.

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