Open AccessInflammation in Depression
Author(s) -
Novi Agung Rahmawati,
Azimatul Karimah,
Mustafa M. Amin
Publication year - 2021
Publication title -
jurnal psikiatri surabaya
Language(s) - English
Resource type - Journals
eISSN - 2716-358X
pISSN - 2355-2409
DOI - 10.20473/jps.v10i2.22045
Subject(s) - depression (economics) , neurotransmitter , norepinephrine , dopamine , serotonin , inflammation , neuroscience , endocrine system , medicine , psychiatry , psychology , central nervous system , receptor , hormone , economics , macroeconomics
Depression is a chronic condition that imposes a substantial burden of disability globally. Three principal neurotransmitters (norepinephrine (NE), dopamine (DA), and serotonin (5-HT)) implicated the pathophysiology and treatment of depression. Clinical studies have found a signicant association between numerous pro-inammatory cytokines with depressive symptoms, endocrine, and neurotransmitter systems. Here, we detail our current understanding about the role of inammation in depression, the mechanisms that are involved, and show how it is possible to innovate and develop new therapeutics of depression in the eld of neuroinammation.