Open AccessPENGARUH KONSENTRASI SURFAKTAN TERHADAP KARAKTERISTIK FISIK NANOEMULSI DAN NANOEMULSI GEL KOENZYM Q10
Author(s) -
Silvi Ayu Wulansari,
Ririn Sumiyani,
Ni Luh Dewi Aryani
Publication year - 2019
Publication title -
jurnal kimia riset
Language(s) - English
Resource type - Journals
eISSN - 2528-0422
pISSN - 2528-0414
DOI - 10.20473/jkr.v4i2.16164
Subject(s) - pulmonary surfactant , dispersity , coenzyme q10 , chemistry , solubility , zeta potential , viscosity , chromatography , materials science , organic chemistry , biochemistry , nanotechnology , composite material , nanoparticle
Coenzyme Q10 is a compound that functions as an antioxidant with a large molecular weight of 863.36 g/mol and has lipophilic properties. This makes coenzyme Q10 need to be formulated to improve the solubility of the material and the delivery system in the skin. This study aims to determine the effect of surfactant variations (a combination of PEG-40 HCO and Span 80) on the physical characteristics of nanoemulsion and nanoemulsion gel preparations. Coenzyme Q10 is formulated using the rice bran oil oil phase with the combination surfactant. This research was made in 3 nanoemulsion formulas FI, F2, F3 and 3 nanoemulsion gel formulas F4, F5, F6. Evaluation of physical characteristics is done after 24 hours after the preparation is complete, observations made include organoleptic (shape, color and phase formed), pH, viscosity, droplet size, zeta potential and polydispersity index. The research data were processed statistically using the Kruskal-Wallis analysis and Mann-Whitney follow-up tests. The results showed that the surfactant concentration affected physical characteristics (viscosity, droplet size, zeta potential and polydispersity index) with a significantly different result (p 0.05)