Open AccessAktivitas Penghambatan Ekstrak Etanol Daun Cassia Spectabilis Terhadap Pertumbuhan Plasmodium falciparum dan Plasmodium berghei
Author(s) -
Wiwied Ekasari,
Nindya Tresiana,
Suciati Iryani,
Tutik Sri Wahyuni,
Heny Arwaty
Publication year - 2017
Publication title -
jurnal farmasi dan ilmu kefarmasian indonesia/jurnal farmasi dan ilmu kefarmasian indonesia
Language(s) - English
Resource type - Journals
eISSN - 2580-8303
pISSN - 2406-9388
DOI - 10.20473/jfiki.v3i12016.17-21
Subject(s) - plasmodium berghei , cassia , traditional medicine , ed50 , plasmodium falciparum , malaria , in vivo , biology , ic50 , in vitro , pharmacology , chemistry , botany , medicine , biochemistry , immunology , microbiology and biotechnology , traditional chinese medicine , alternative medicine , pathology
Background: Antimalarial screening against nine species of the genus Cassia showed that the methanol extract of leaves Cassia spectabilis have the highest activity. Since it will be used as a traditional medicine, hence it is needed further studies of antimalarial activity of these plants by choosing a safer solvent, namely ethanol. Objective: In vitro anti-malarial activity against Plasmodium falciparum was conducted using the method of Trager and Jensen. Methods: The serial solution tested were: 100, 10, 1, 0.1 and 0.01 µg/ mL, while the in vivo test was performed based on Peter’s test (The days suppressive test) that using P. berghei (strain ANKA) infected mice. Results: The results showed that ethanolic extract of C. spectabilis leaves has inhibitory activity against P. falciparum with IC50 value of 12.52 µg/ mL and against P. berghei with ED50 value of 131.5 mg/kg body weight. Conclusions: A further study to see the potential of ethanol extract from C. Spectabilis leaves as anti-malaria is warranted.