Open AccessCOMPARISON OF MORTALITY BETWEEN THE COMBINATION OF STANDARD THERAPY AND CONVALESCENT PLASMA THERAPY AND STANDARD THERAPY ONLY IN COVID-19 PATIENTS : SYSTEMATIC REVIEW AND META-ANALYSIS
Author(s) -
Felicia Klarin,
Angelica Diana Vita,
Cynthia Elvira Sari Siahaan,
Salsabila Nabilah Rifdah,
Aurellia Nuraini Anindito Putri,
Indriasti Putri Kusuma,
Subur Prayitno
Publication year - 2021
Publication title -
journal of community medicine and public health research
Language(s) - English
Resource type - Journals
ISSN - 2723-035X
DOI - 10.20473/jcmphr.v2i2.27432
Subject(s) - medicine , convalescent plasma , meta analysis , pharmacotherapy , combination therapy , covid-19 , intensive care medicine , disease , infectious disease (medical specialty)
Coronavirus Disease-19 (COVID-19) is an infectious disease caused by a newly discovered type of coronavirus. Comprehensive management for COVID-19 patients includes infection control, hemodynamic stability maintenance, oxygenation monitoring, ventilation, and pharmacotherapy administration. Convalescent plasma is one of the COVID-19 therapy choices, proven to provide relief for Ebola, SARS, and MERS patients. Therefore, the authors believed in searching data on whether convalescent plasma therapy also improves COVID-19 patients, specifically in terms of mortality. This study aims to compare the comparison in mortality between standard therapy and convalescent plasma therapy with standard therapy only in COVID-19 patients. This study used a systematic review and meta-analysis method according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. This study used ten studies that met the inclusion criteria to evaluate the comparison in mortality between the combination therapy with standard therapy only in COVID-19 patients. There was a significant difference in mortality between the combination of standard therapy and convalescent plasma therapy with standard therapy only in COVID-19 patients, and mortality in the combination therapy groups being lower than standard therapy only.