Open AccessCorrelation of Mothers with History of Diabetes Mellitus and Infants with Anti-GAD65
Author(s) -
Nanda Fadhilah Witris Salamy,
Gadis Meinar Sari,
Bambang Purwanto,
Sulistiawati Sulistiawati
Publication year - 2021
Publication title -
folia medica indonesiana
Language(s) - English
Resource type - Journals
eISSN - 2599-056X
pISSN - 2355-8393
DOI - 10.20473/fmi.v55i4.24474
Subject(s) - medicine , diabetes mellitus , transplacental , pregnancy , gestational diabetes , family history , antibody , pediatrics , observational study , cohort , medical history , obstetrics , endocrinology , gestation , immunology , fetus , biology , placenta , genetics
This study aimed to determine the relationship between mothers with history of diabetes mellitus with Infants with Anti-GAD65. This study was an observational analytic study with a cohort study design. The case studied was the relationship between maternal history of diabetes mellitus and infants with Anti-GAD65. This study was conducted at Jemursari Hospital in Surabaya. Sample examination was performed with a GAD65 autoimmune rapid test. Then, a statistical test was performed to determine its relationship with other variables. There was no relationship between mothers with history of diabetes mellitus and infants with Anti-GAD65, but there was a significant relationship between Anti-GDA65 Mothers with Infants with Anti-GAD65. Thus, there was a possibility of transplacental antibody transfer and viral infections during pregnancy that cause damage to pancreatic beta cells. History of diabetes mellitus was not related to infants with Anti-GAD65, but there was a relationship between Anti-GAD65 Mothers with Anti-GAD65 BAyi so that there is a transfer of transplacenta antibodies and viral infections during pregnancy that can cause damage to beta pancreatic cells in infants.