Open AccessGLUT-1 IS A PROMISING TARGET FOR ATP DEPLETION ON DIABETIC ENERGY DEFICIENCY SYNDROME
Author(s) -
Bambang Purwanto,
Harjanto Harjanto,
Elyana Asnar
Publication year - 2017
Publication title -
folia medica indonesiana
Language(s) - English
Resource type - Journals
eISSN - 2599-056X
pISSN - 2355-8393
DOI - 10.20473/fmi.v53i3.6443
Subject(s) - glucose transporter , diabetes mellitus , medicine , endocrinology , streptozotocin , presentation (obstetrics) , insulin , transporter , chemistry , biochemistry , surgery , gene
Diabetes is a metabolic syndrome which characterized with insulin insensitivity, lack of GLUT-4 membrane presentation and ATP deficiency. ATP is needed for substrate phosphorylation, signalling pathways, protein translation and cellular survival. Since GLUT-1 was discovered as alternative glucose transporter on muscle membrane, some studies started to investigate it more. This study aimed to investigate GLUT-1 presentation on diabetes muscle membrane of rat model in time. Diabetes was obtained from a 50 mg/kg B.W of streptozotocin intra peritoneal injection on rat. We found that GLUT-1 presentation increased significantly in time of diabetic stages. It correlated negatively with GLUT-4 presentation and mortality. Eccentric downhill running on diabetic rat model improved GLUT-1 presentation and blood glucose level. It was promising for diabetes management therapy at the future.