Open AccessOrgan Damage due to Elevation of Blood Pressure on NaCl-induced
Author(s) -
Hotimah Masdan Salim,
Ilham Putra Alam,
Widya Dio Kharisma
Publication year - 2020
Publication title -
biomolecular and health science journal
Language(s) - English
Resource type - Journals
ISSN - 2620-8636
DOI - 10.20473/bhsj.v3i2.22089
Subject(s) - blood pressure , medicine , kidney , left ventricular hypertrophy , myocardial hypertrophy , cardiac hypertrophy , endocrinology , cardiology , diastole , intraperitoneal injection , muscle hypertrophy
High salt diet is known to induce or aggravate hypertension in hypertensive rats and humans. The elevation of blood pressure by NaCl-induced promotes cardiac hypertrophy, the impairment of left ventricular relaxation, endothelial dysfunction, and kidney injury. This study aimed to examine whether NaCl-induced caused increase blood pressure and weight of organs. Methods: Eight weeks old male Mus musculus were divided to two groups, one group was given NaCl 8% by intraperitoneal injection for 8 hours.Results: Blood pressure was measured previously, in this study systolic and diastolic blood pressure increased significantly (p < 0.05). The increasing of blood pressure was followed by significant increase in organ weight, such as heart and kidney (p < 0.05). Conclusion: This result suggested that NaCl-induced caused hypertension and increased organs weight that may cause early process of damages in organs.