Open AccessEFFECT OF Polygonum minus (KESUM) LEAVES ETHANOLIC EXTRACT ON HISTOPATHOLOGICAL CHANGES ON THE WALL AORTA OF MICE (Mus musculus) INDUCED BY CADMIUM CHLORIDE ANTIOXIDANT
Author(s) -
Putri Anggraheni Kusumaningrum,
Lita Rakhma Yustinasari,
Iwan Sahrial Hamid,
Sri Agus Sudjarwo,
Kuncoro Puguh Santoso,
Chairul Anwar
Publication year - 2020
Publication title -
journal of basic medical veterinary
Language(s) - English
Resource type - Journals
ISSN - 2774-9959
DOI - 10.20473/.v8i2.20408
Subject(s) - cadmium , cadmium chloride , polygonum , chemistry , positive control , chloride , negative control , aorta , traditional medicine , decoction , medicine , organic chemistry
This study was conducted to investigate the protective effect Polygonum minus leaves extract on the histopathological changes on aorta wall of mice (Mus musculus) induced by cadmium chloride. Thirty male mice were divided into five groups and were administered via intragastric gavage with different treatments for 21 days. The treatment were Negative Control (CMC Na 0.5% solution + aquadest), Positive Control (CMC Na0.5% solution + 8 mg/kg bw of mercuric chloride), Treatment 1, 2, and 3 (200, 400, and 800 mg/kg bw of Polygonum minus leaves extract respectively + 8 mg/kg bw of cadmium chloride). The microscopec examine followed analyzed by One Way ANOVA continued with Duncan test for counting the amount of foam cell and the histopathological changes of wall aorta were examined by using Ifora Scoring method was analysed using Kruskal Wallis and continued with Mann-Whitney test. The result showed Polygonum minus leaves extract could protect wall aorta of mice from the damage effect of cadmium chloride. The best dose of Polygonum minus on this research was 400 mg/kg bw.