Open AccessAnsofaxine Hydrochloride
Author(s) -
Vjekoslav Peitl,
Darko Vlahović
Publication year - 2020
Publication title -
archives of psychiatry research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.117
H-Index - 8
eISSN - 2671-2008
pISSN - 2671-1079
DOI - 10.20471/may.2020.57.01.09
Subject(s) - prodrug , reuptake inhibitor , reuptake , dopamine , pharmacology , norepinephrine , norepinephrine transporter , chemistry , hydrochloride , serotonin , medicine , biochemistry , receptor
Ansofaxine hydrochloride (LY03005; LPM570065) is a triple reuptake inhibitor that inhibits serotonin, dopamine and norepinephrine reuptake. This novel triple reuptake inhibitor is a carboxylic acid ester prodrug of desvenlafaxine. It is currently under development for the treatment of major depressive disorder - a frequent and heterogeneous disorder induced by a complex pattern of genetic, epigenetic, developmental, and environmental factors.